Although, as stated previously (17) that PKCε has been shown to direct integrin‐β1 trafficking, it has furthermore been shown to direct the integrin‐dependent adhesion and motility of human glioma cells, inducing focal adhesion and lamellipodia formation with the suggestion that the RACK1 scaffolding protein mediates integrin beta chain interaction with activated PKCε(4). Here, RACK1 is linked to central nervous system cancer.