The melioidosis mouse model in which B. pseudomallei is delivered per the intranasal route has been proven successful in mimicking pneumonia-derived septic melioidosis [13], [14], [17], [19]–[21], [35], [36] and the availability of MyD88 and TRIF deficient mice enabled us to further elucidate the predominant TLR signaling routes involved in melioidosis. Here, MYD88 is linked to susceptibility to pneumonia measurement.