Lis1, a mutation of which underlies human lissencephaly, is a regulatory protein of the microtubule motor dynein, and is highly conserved from human to Drosophila. Drosophila Lis1 has been shown to play an essential role in MB neurogenesis and dendritic elaboration [35]–[37]. Here, PAFAH1B1 is linked to Lissencephaly.