TP53 and neoplasm: Dose-dependent accumulation of p53 leading to apoptosis and cell cycle arrest after stimulation with luteolin (53 and 110 μM), apigenin and quercetin was also reported by Plaumann [24] for the non-tumor mouse embryo fibroblast cell line C3H10T1/2CL8;the effects of luteolin and apigenin were long-lasting, while quercetin induced p53 accumulation only for 1-2 hours unless supplied continuously.