Pretreatment with a noncytotoxic concentration of 40 μM luteolin significantly sensitized TRAIL-induced apoptosis in both TRAIL sensitive (HeLa) and TRAIL resistant cancer cells (CNE1, HT29, and HepG2) through enhanced caspase 8 activation and caspase 3 maturation [74]. Here, TNFSF10 is linked to cancer.