Mutant mice relevant to both the dopamine and glutamate hypotheses of schizophrenia similarly show working memory deficits, including mice lacking D2 and D3 receptors [53], mice with transient striatal overexpression of D2 [54], GluR1 knockout mice [55] and mice with dentate gyrus specific NMDA receptor knockout [56]. Here, GRIA1 is linked to schizophrenia.