In multivariate analyses that included the baseline covariates described in Methods for adjusted analyses, age (p = 0.02), smoking (p = 0.01), prior CVD (p = 0.04), co-infection with hepatitis B or C (p = 0.03), and baseline CD4+ cell count (p = 0.10) were associated (p = 0.10 or lower) with mortality. The gene discussed is CD4; the disease is hepatitis B virus infection.