Specifically, one large cluster is involved in cell proliferation and cycle progression, including HVC-enriched genes that mediate non-p53 tumor suppression (AIM1, GBAS, NETO1, UBE2E1; LMO2, LMO3), interact with cyclin D1 (SYF2), or generally relate to cell proliferation (QSCN6), as well as a variety of markers of low expression associated with tumor suppression, growth arrest and/or proliferation. The gene discussed is QSOX1; the disease is neoplasm.