Using MAbs specific for conformational, non-neutralising epitopes of the FMDV capsid, we identified viral structural proteins restricted to the light zone FDC network of GCs within mandibular lymph nodes, lateral retropharyngeal lymph nodes and palatine tonsils up to 38 days post contact infection, but not in the dorsal soft palates or pharyngeal tonsils. This evidence concerns the gene PROS1 and infection.