Given the encouraging results obtained by the combination of capecitabine and vinorelbine in advanced breast cancer and the synergism with bevacizumab shown by both drugs, we thereby decided to investigate the combination of bevacizumab, capecitabine and vinorelbine and endocrine therapy in patients with ER- and/or PgR-positive locally advanced breast cancer. The gene discussed is PGR; the disease is breast carcinoma.