CD8A and metastatic malignant neoplasm in the lymph nodes: In addition, densities of CD3+, CD8+ and CD45RO+ TILs and the combined TIL densities remained significant predictors of overall survival by multivariate Cox proportional hazard analysis, even after controlling for T stage, histologic classification (WHO), presence of lymph node metastasis, and presence of lymphatic invasion, which were all found to be of prognostic significance by univariate analysis (Tables 5 and 6).