In terms of lymph node metastasis, Taylor et al (2007) reported that brisk TIL infiltration in tumour predicts sentinel lymph node metastasis in melanoma patients, and Piersma et al (2007) demonstrated that a high number of intraepithelial CD8+ TIL is associated with the absence of lymph node metastasis in uterine cervical cancer. The gene discussed is CD8A; the disease is metastatic malignant neoplasm in the lymph nodes.