In terms of lymph node metastasis, Taylor et al (2007) reported that brisk TIL infiltration in tumour predicts sentinel lymph node metastasis in melanoma patients, and Piersma et al (2007) demonstrated that a high number of intraepithelial CD8+ TIL is associated with the absence of lymph node metastasis in uterine cervical cancer. This evidence concerns the gene CD8A and neoplasm.