The FasL staining pattern in the cytoplasm was granular, an expression pattern that has also been observed in ovarian carcinoma and melanoma, where FasL is stored in cytoplasmic microvesicles and, upon release, induces apoptosis in Fas-bearing immune cells (Andreola et al, 2002; Abrahams et al, 2003; Arts et al, 2005). The gene discussed is FAS; the disease is melanoma.