INS and septic shock: Patients with septic shock had an increased duration of continuous and overall insulin therapy (duration of continuous therapy in median (IQR): sepsis: 83.4 hours (50.3 to 166.4 hours), severe sepsis: 101.1 hours (18.4 to 199.7 hours), septic shock: 217.6 hours (110.8 to 466.1 hours), p = 0.0001; duration of overall insulin therapy: sepsis: 134.0 hours (72.1 to 251.4 hours), severe sepsis: 184.3 hours (93.7 to 310.7 hours), septic shock: 320.2 hours (158.0 to 789.9 hours), p < 0.0001).