Similarly, the median insulin dose per day applied over the entire ICU stay was higher for patients with septic shock (median (IQR) insulin dose per day: sepsis: 33.2 IU (22.7 to 47.6 IU), severe sepsis: 36.3 IU (21.4 to 48.7 IU), septic shock: 45.0 IU (34.6 to 68.9 IU), p = 0.0005). The gene discussed is INS; the disease is Sepsis.