Chronic high dose Ang II infusions over the period used in this study were shown to result in production of signs of vascular inflammation and endothelial dysfunction by the end-point, but have not been studied at the early time point (~7 day) at which we observed consistent differences in the trend for hemodynamic changes of PAR2 -/- [18,19]. Here, F2RL1 is linked to endothelial dysfunction.