PON1 and type 2 diabetes mellitus: We have also shown that HDL from people with Type 2 diabetes and those with CHD is significantly less able to metabolize erythrocyte membrane lipid hydroperoxides than control HDL and there is a significant linear relationship between lipid hydroperoxide metabolism and HDL-PON1 activity in control subjects but not in people with Type 2 diabetes or those with CHD, indicating a derangement in the ability of HDL to metabolize lipid peroxides in these people as we have found previously [22].