Analyses of PRNP from 135 patients reported in CJD surveillance revealed again that most cases (131, 97.0%) were methionine homozygous genotype at codon 129, four (3.0%) were methionine/valine heterozygosity and none was valine/valine homozygous, which corresponding well with our previous results[13]. The gene discussed is PRNP; the disease is Creutzfeldt Jacob disease.