Many transcripts involved in cell signalling were changed by TNBS colitis, including genes encoding proteins that participate in cAMP/protein kinase A and calcium/protein kinase C pathways, phosphatases, various regulatory proteins and a number of transmitter/hormone receptors, including P2ry6, Htr2b, Prlr, Sstr1, Tacr2 and Thra. This evidence concerns the gene PRLR and colitis.