CD4 and AIDS: Recently, Pahar et al. [32] using vaginal SHIVSF162P3 challenge observed control of viremia with modest depletion of the memory CD4+ T cell subset; however, these animals were followed only until day 84 p.i. Overall, SHIVSF162P3 induced progressive disease leading to AIDS in 6 out of 11 rhesus monkeys with systemic infection after intravaginal challenge [33]; the time to development of AIDS varied from 5.5 weeks to 104 weeks p.i SHIVSF162P3 was adapted to rhesus monkeys cumulatively over a time span of 26 weeks.