RUNX1T1 and leukemia: It is frequently rearranged in myeloid malignancy either through fusion to ETO as a result of t(8;21)(q22:q22) or to EVII, MDS1, or EAP as a result of t(3;21)(q26:q22).[2,22] The frequent involvement of TEL and AML-I in chromosomal translocations suggests that these genes play important roles in the pathogenesis of human leukemia.