We genotyped thesefour TLR8 polymorphisms in an independent collection of 1,837pulmonary TB patients and 1,779 controls from Russia and again found evidence ofassociation in males (for rs3764880P = 0.03,OR = 1.2, 95%c.i. = 1.02–1.48). Here, TLR8 is linked to tuberculosis.