In three month old mice harboring three familial AD-linked mutations (APPSwe, tauP301L, and PS1M146V) which lead to accumulation of intraneuronal amyloid immunoreactivity in regions that include entorhinal cortex, elevated TNF mRNA levels were reported in the same regions and correlated with the onset of cognitive deficits in these mice [174,175]. This evidence concerns the gene TNF and Cognitive impairment.