Levels of TIAM-1 were much lower in tumour tissue from patients who remained disease free compared with those who died from breast cancer (median value disease free, 60.3 v median value died from breast cancer, 224.5; p = 0.04, with range Q1–Q3 disease free 0 – -251.1; died from breast cancer 0 – -3.2). This evidence concerns the gene TIAM1 and neoplasm.