Immunodetection has shown that nestin is expressed in many kinds of tumors, especially in tumors derived from CNS (e.g., central neurocytomas, gangliogliomas, ependymomas, pilocytic astrocytomas, high-grade gliomas including glioblastoma multiforme), and embryonal tumors originating from the CNS (primitive neuroectodermal tumors – PNETs, medulloblastomas, and medulloepitheliomas) [5,11-24]. The gene discussed is NES; the disease is glioblastoma.