PCNA and neoplasm: Y-box binding protein-1 (YB-1) is a transcription and translation factor that can promote tumor growth and chemotherapy resistance by inducing growth-promoting genes such as HER-2 and EGFR (epidermal grwoth factor receptor) [9], PCNA (proliferating cell nuclear antigen) [10], MDR-1/ABCA1 (multi-drug resistance-1) [11], cyclin A [12], and cyclin B [12].