Seven probes were screened in the region associated with Miller-Dieker lissencephaly syndrome and Canavan disease in 17p13-pter, in HIC1, MGC3329, PAFAH1B1, ASPA, and TRPV1. In a boy with a diagnosis of autism, we observed an apparent deletion in a probe within the ASPA gene involved in Canavan disease. This evidence concerns the gene PAFAH1B1 and Miller-Dieker lissencephaly syndrome.