High levels of circulating PAI-1 contribute to the development of MI, coronary artery disease, and pathologic thrombosis (Dellas & Loskutoff, 2005; Gils & Declerck, 2004; Hamsten et al., 1987; Juhan-Vague et al., 1987; Vaughan, 2005), worsen the prognosis of patients suffering from MI, and are routinely observed in atherosclerotic plaques, macrophages, and endothelial cells of people diagnosed with cardiac diseases (Schneiderman et al., 1992). This evidence concerns the gene SERPINE1 and myocardial infarction.