In addition, while young children are capable of mounting strong IFN-γ responses to Mtb antigens, it remains to be determined whether or not difference in other aspects of the T cell response to Mtb could predispose children to development of active TB, such as excessive Th2, Th17, and/or T regulatory responses and/or deficient CD8+ T cell responses. The gene discussed is IFNG; the disease is tuberculosis.