CD4 and acute disseminated encephalomyelitis: The data provide evidence that the risk of serious ADE was significantly higher for naives compared to those who started cART, only for CD4 <350/mm3, before adjusting for current HIV RNA (RR and 95%CI= 1.68, 1.07-2.62 and 2.06, 1.57- 2.71 respectively for CD4 strata 200-350 and <200 cells/mm3).