The differential abundance of PGRMC1 protein between breast cancers of different ER-α status is notable because we previously identified the distantly related cytochrome b5-domain feudesin/SPUF protein and cytochrome b5 itself to have been slightly yet significantly differentially abundant between breast tumors that were all positive for the ER-α but which differed in the expression level of the cytoplasmic progesterone receptor [19]. The gene discussed is CYB5A; the disease is breast cancer.