BIRC5 and neoplasm: With respect to the role of survivin in resistance against radiation-induced apoptosis in tumour cells under normoxia, the overexpression of dominant-negative mutants of survivin (T34A and D53A) was demonstrated to enhance radiation-induced apoptosis in mouse fibroblast cell line NIH3T3, human cervical carcinoma cell line HeLa and human lung carcinoma cell line A549 (Ogura et al, 2008).