Quantitative data showed that X-irradiation (2 Gy) alone had little effect on HIF-1α expression (40.0±2.4%) compared with the control (38.1±4.1%), but it was significantly suppressed to 15.2±1.3 and 15.1±2.6% in the tumours treated with TAS106 alone and the combination of X-irradiation and TAS106, respectively (Figure 8B). Here, HIF1A is linked to neoplasm.