Although several reports show risk association of the SULT1A1 variant with different cancers (Sun et al, 2005; Dandara et al, 2006; Pachouri et al, 2006; Fan et al, 2007; Lilla et al, 2007; Bardakci et al, 2008), others show either no effect (Sellers et al, 2005) or a protective effect (Cheng et al, 2005). The gene discussed is SULT1A1; the disease is cancer.