Appierto et al., (2004)could observe an involvement of c-Fos in fenretinide-induced apoptosis in human ovarian carcinoma cells. In their study, apoptosis was accompanied by elevation of c-Fos expression at mRNA and protein level. This observation supports our results, which demonstrate an association of reduced c-Fos expression with adverse outcome (Figure 3, Tables 3 and 4). Here, FOS is linked to ovarian carcinoma.