As our expected, Ganoderma lucidum polysaccharides have been shown that can modulate the concentrations of IL2, IFNG, TNF, and NFKB1 in patients with advanced colorectal cancer [36], and ganoderic acid Me can inhibit tumor growth and lung metastasis through increasing the expressions of IL2, IFNG and NFKB1 [37]. This evidence concerns the gene TNF and colorectal cancer.