TNF and Familial prostate cancer: Recent studies have shown that Ganoderma lucidum can induce apoptosis of prostate cancer cells (PC-3) via decreasing the expression of NFKB1-regulated genes [34] and Ganoderma lucidum is able to inhibit TNF-induced proliferation of human breast cancer cells through modulation of the NFKB1 signaling [35].