However, other hypotheses have been presented, mostly relating to specific skin changes in ALS patients such as the “late-return phenomenon” (when the skin of such patients is stretched, it tends to return to its normal position rather slowly).9-11 Kolde et al.,12 among other authors, further demonstrated disorganization of the elastin and collagen layers of the skin of ALS patients, with beta-amyloid deposits. Here, ELN is linked to amyotrophic lateral sclerosis.