From all these observations it can be postulated that the molecular pathway of carcinogenesis by methyl-imbalanced diet may be the following: a methyl-imbalanced diet — chronic low SAM/SAH ratio in most cells of a diet-responsive target tissue —inhibition and downregulation of RIZ1 in most cells of the target tissue — upregulation of prosurvival and progrowth oncogenes such as c-Jun in most cells of the target tissue — stochastic accumulative genetic and epigenetic changes in a single cell — clonal proliferation of the single cell — cancer. The gene discussed is PRDM2; the disease is cancer.