We also suspect that a similar pathway is promoted by FANCM in humans, and in this regard it is interesting to note that the FA core complex copurifies with the Bloom syndrome complex, which contains the orthologs of Rqh1 (=BLM), Top3 (=Top3α), and Rmi1 (=BLAP75) (Wang, 2007). The gene discussed is TOP3A; the disease is Bloom syndrome.