The management of membranous glomerulonephritis in a patient with HAE would be challenging as angiotensin converting enzyme inhibitors (ACEIs) and angiotensin 2 receptor blockers (ARBs) which effectively reduce proteinuria and slow the progression of the renal disease [2] cause angioedema which precludes their use in patients with HAE [3]. Here, AGTR2 is linked to hereditary angioedema.