PRNP and prion disease: The glycoform ratios of protease-resistant PrP fragments in these kuru isolates were all similar to the PrP glycoform ratios seen in classical CJD rather than the distinctive PrP glycoform ratios seen in either vCJD or inherited prion disease caused by PRNP point mutations (Hill et al.2003, 2006; Wadsworth et al. 2006; Wadsworth & Collinge 2007; figure 1).