In this study we used an endotoxicosis animal model and a sepsis animal model to provide evidence of the beneficial effects of administration of erythro-9-[2-hydroxy-3-nonyl] adenine (EHNA), a specific ADA1 and PDE2 inhibitor, on the production of adenosine metabolites and intestinal permeability, and improved survival rates. The gene discussed is ADA; the disease is Sepsis.