A systematical review of the literature on the effects of genistein on breast cancer cell growth was performed by de Lemos, and concluded that at low (<10 μmol/L) physiologically relevant levels, genistein stimulates estrogen receptor positive (ER+) tumors, while at higher (>10 μmol/L) concentrations, appears to be inhibitory. The gene discussed is ESR1; the disease is breast carcinoma.