PTH and osteoporosis: PTH(1-34) is an anabolic agent; hPTH(1-34) has also been approved for the treatment of osteoporosis and is effective in improving bone strength and reducing vertebral and nonvertebral fracture risk in postmenopausal women.(6) Daily injections of hPTH(1-34) result in a rapid increase in new bone formation followed by coupled bone remodeling for the duration of the therapy.(7) Trabecular bone is the primary surface on which PTH initially changes with increases in double labeled surface and thickness of the trabeculae.