WNT4 and Severe short stature: In a chick model, Wnt-4 blocks the initiation of chondrogenesis and accelerates terminal chondrocyte differentiation.(15–17) Conditional expression of Wnt-4 during chondrogenesis also leads to dwarfism in mice through inhibition of growth plate chondrocyte proliferation and promotion of hypertrophy.(18) In this study, we confirmed that Wnt-4 plays a key role in the thyroid hormone-mediated terminal differentiation of growth plate chondrocytes.