In a post hoc analysis of the KORA S4 and ISAAC replication cohorts, FCER1A polymorphisms rs2251746 and rs2427837 showed association with allergic sensitization (P = 7.78×10−4 and 1.95×10−3 in KORA, P = 0.025 and 0.032 in ISAAC), while there were no significant associations for the dichotomous traits asthma, rhinitis and atopic eczema (AE). The gene discussed is FCER1A; the disease is asthma.