TP53 and cancer: We tested the hypothesis that these mutations were frequent in cancer genes, by studying again TP53. Our assay showed that single nucleotide frame-shifts associated to cancer were non-randomly enriched in TP53. When looking for frame-shifts induced by 1 nucleotide insertions/deletions, an analogous test to that for pAA was designed, as detailed in Experimental Procedures, to generate pFrameshift.