CYP2B6 and insomnia: Side effects:Insomnia, dry mouthDrug interactions:Clearance of bupropion may be ↓ by inhibitors (for example, ticlopidine) or ↑ by inducers (for example, phenobarbital, phenytoin, primidone) of CYP2B6. May ↓ clearance of other substrates of CYP2B6 (for example, cyclophosphamide, ketamine, promethazine, propofol, selegiline). MAOIs, levodopa, amantadine may ↑ toxicity. May be safely combined with NRT (monitor for treatment-emergent hypertension)