In vivo, CT26 cells also expressed LFA-1 integrin since their earliest 3D-growth of non-hypoxic avascular micrometastasis in the liver, suggesting that 3D-growth-dependent features endowed colorectal cancer cells with an enhanced capability to produce VEGF in response to ICAM-1 provided by tumor-activated hepatic cells. Here, ICAM1 is linked to neoplasm.