ICAM1 and leukemia: Previous studies have already reported that expression of this integrin contributes to hepatic invasion and metastasis of lymphoma, leukemia and breast cancer cells [22,23]; that LFA-1 blockade using specific antibodies can inhibit the hepatic colonization process [24]; and that ICAM-1 deficient mice can prevent post-homing events contributing to the hepatic colonization of T-lymphoma cells [25].