This study demonstrates that culture of CT26 cancer cells as multicellular spheroids leads to the expression of a distinct proangiogenic protein profile, including the specific expansion of a LFA-1-expressing cancer cell subpopulation able to interact with ICAM-1-expressing hepatic endothelial cells and myofibroblasts, and to increase VEGF secretion in response to membrane and soluble ICAM-1, via COX-2-dependent mechanism (Figure 3B). The gene discussed is PTGS2; the disease is cancer.