The R24P mutation alters a highly conserved residue in the first ankyrin repeat, is closely linked with familial melanoma in at least 11 melanoma-prone kindreds (Della Torre etal., 2001; Mantelli etal., 2002; Goldstein etal., 2006a) but behaved as wild-type p16INK4a in CDK6-binding assays (Harland etal., 1997; Jones etal., 2007). This evidence concerns the gene CDKN2A and melanoma.