CDK4 germline mutations have been identified in eight melanoma-prone families worldwide (Zuo etal., 1996; Soufir etal., 1998; Molven etal., 2005; Pjanova etal., 2007; Soufir etal., 2007) and these disrupt the interaction between p16INK4a and CDK4 (Zuo etal., 1996). The gene discussed is CDKN2A; the disease is melanoma.