In this model, an association between peripheral blood leukocyte PDGFR phosphorylation and plasma PDGF kinetics following pre-operative docetaxel therapy with spatial and quantitative assessment of tissue PDGF and phosphorylated PDGFR activation in the neoplastic, vascular and stromal components of tumour microenvironment at surgery will be studied. The gene discussed is PDGFRB; the disease is neoplasm.