To determine whether APC promoter hypermethylation affects protein expression in breast tumours, we assessed the association between APC methylation levels by qMSP and loss of APC protein expression by immunohistochemistry in 34 of 54 (63%) breast tumours (including 22 cases of non-IBC and 12 cases of IBC) (Figure 4). Here, APC is linked to breast neoplasm.