In the present study we found that there was an increase in VEGF expression in the HPV only infected cervices, reaching the highest point in the invasive cancer cases, which is consistent with other report [4] that described a linear increasing from low grade CIN to high grade CIN and cancer lesions, suggesting that VEGF is a diagnostic marker for early stages of cervical carcinogenesis. The gene discussed is VEGFA; the disease is cervical squamous intraepithelial neoplasia.