Twelve years later, in 2005, the patient presented with incapacitating fatigue related to severe iron deficiency anaemia (Hb 75 g/litre, MCV 64.6 fl, MCHC 299 g/litre, reticulocytes 13‰, ferritin 6 ng/ml and soluble transferrin receptor 13.4 mg/ml (normal range 2.2 to 4.5 mg/ml)). Here, GSTM1 is linked to Iron deficiency anemia.